Visiting NCRR Team Briefed on RMATRIX

Program officials and staff from the National Center for Research Resources (NCRR) at the National Institutes of Health visited the University of Hawai‘i at Mānoaʻs John A. Burns School of Medicine (JABSOM) the week of August 22, to hear about the progress on the Clinical & Translational Research Award called “R-MATRIX”.

R-MATRIX stands for Research Centers Minority Institutions Multidisciplinary and Translational Research Infrastructure Expansion. It supports research collaborations and partnerships among university and community-based basic, clinical and translational researchers who are focused on reducing health disparities affecting Hawai’i’s diverse ethnic communities. The focus is on: Cardiovascular Health, Respiratory Health, Perinatal, Growth and Developmental Health, Nutrition and Metabolic Health, Aging and Neurocognitive Health, and Cancer.

Awarded in November 2010, the grant provides an opportunity to renew and extend the clinical and translational research activities into other national collaborations. JABSOM is the backbone for this award that will complement many areas of excellent health disparities research that are already underway in Hawai’i.

To link to websites for each of the main programs, scroll further down this page. 

Meanwhile, last month, Dean Jerris Hedges announced eight new awards for the 2011 RMATRIX Collaboration Pilot Projects Program.

During the current cycle, the RMATRIX program received 27 applications representing unique collaborations between physicians and basic scientists, community workers and clinicians, and investigators in disparate disciplines, with research proposals addressing all of the RMATRIX HEALTH Initiatives. The applications were evaluated through an NIH-based review process, and several outstanding applications emerged. The new awards are:

Project Protection from Cardiac Hypertrophy via Pharmacological Inhibition of the Ion Channel TRPV1

Principal Investigator Alexander Stokes, PhD, Department of Cell & Molecular Biology, UH JABSOM, Collaborator Abby Collier, PhD, Department of Tropical Medicine, Medical Microbiology & Pharmacology, UH JABSOM. HEALTH Initiative(s) Cardiovascular Health. Amount $30,000.

Project PILI ‘Aina Project: Partnerships to Overcome Obesity Disparities in Hawai’i

Principal Investigator J. Keawe‘aimoku Kaholokula, PhD, Department of Native Hawaiian Health, UH JABSOM, Collaborator Claire Hughes, MD, Hawai‘i Maoli – Association of Hawaiian Civic Clubs, Collaborator Bridget Kekauoha, Kula No Na Po‘e Hawai’i, Papakolea Hawaiian Homestead Community, Collaborator Donna Palakiko, RN, MS, Ke Ola Mamo Native Hawaiian Health Care System, Collaborator Sheryl Yoshimura, MPH, RD, Kokua Kalihi Valley Comprehensive Family Services, HEALTH Initiative(s) Nutrition & Metabolic Health. Amount $30,000.

Project Thyroid Cancer and Ethnic Disparity in Hawai’i: Profiling the MAPK and MTOR Signaling Pathways

Principal Investigator Shane Morita, MD, Department of Surgery, UH JABSOM, Collaborator Christopher Lum, MD, Departments of Medicine & Pathology, UH JABSOM, Collaborator James Davis, PhD, Research Design & Biostatistics, RMATRIX, UH JABSOM.HEALTH Initiative(s) Cancer. Amount $25,000.

Project Neuroimaging Correlates of Monocyte/Macrophage Infiltration in HIV-infected Individuals: A Cross-sectional Pilot Study Using IV Furomoxytol

Principal Investigator Beau Nakamoto, MD, Department of Medicine, UH JABSOM, Collaborator Bronwyn Hamilton, MD, Department of Diagnostic Radiology, Oregon Health Sciences University, Collaborator Cecilia Shikuma, MD, Deparment of Medicine, UH JABSOM,Collaborator Bruce Shiramizu, MD, Departments of Pediatrics & Medicine, UH JABSOM, HEALTH Initiative(s) Aging & Neurocognitive Health, Amount $22,200.

Project Correlation of Genetic Risk Factors with Gestational Diabetes and Preeclampsia in Women from Hawai’i

Principal Investigator Johann Urschitz, PhD, Department of Anatomy, Biochemistry & Physiology, UH JABSOM, Co-Principal Investigator, Janet Burlingame, MD, Department of Obstetrics & Gynecology, UH JABSOM, Collaborator Thomas Slavin, MD, Department of Pediatrics, UH JABSOM. HEALTH Initiative(s) 1) Perinatal Growth & Developmental Health; and 2) Nutrition & Metabolic Health. Amount $21,428.

Project Effect of Corticosteroids on Pulmonary Surfactant of Premature Newborns

Principal Investigator Yi Zuo, PhD, Department of Mechanical Engineering, UH College of Engineering, Co-Principal Investigator Charles R. Neal, Jr., MD, PhD, Department of Pediatrics, UH JABSOM, HEALTH Initiative(s) 1) Respiratory Health; and 2) Perinatal Growth & Developmental Health, Amount $29,257.

Project Discrimination and Substance Abuse Among Adolescents in Hawai’i

Principal Investigator Thomas Wills, PhD, Prevention & Control Program, University of Hawai’i Cancer Center, Co-Principal Investigator J. Keawe‘aimoku Kaholokula, PhD, Department of Native Hawaiian Health, UH JABSOM, Collaborator Frederick Gibbons, PhD, Department of Psychological & Brain Sciences, Dartmouth College, HEALTH Initiative(s) 1) Cancer; and 2) Aging & Neurocognitive Health. Amount $30,000.

Project Identification and Characterization of Cryptic Fleming Bay Marine Stingers

Principal Investigator Angel Yanagihara, PhD, Department of Tropical Medicine, Medical Microbiology & Pharmacology, UH JABSOM, Collaborator Jason Smith, MD, Department of Emergency Medicine, U.S. Army Special Forces Underwater Operations, Collaborator Allen Collins, PhD, National Museum of Natural History, Smithsonian Institution, HEALTH Initiative(s) Cardiovascular Health, Amount $20,548.

For more information about our RMATRIX programs, see:

COBRE: PI – Ralph Shohet–Grant Program:  Center for Cardiovascular Research  (CCR)

COBRE:  PI – W. Steve Ward–Grant Program:  Institute for Biogenesis Research (IBR)

COBRE:  PI – Ric Yanagihara-Grant Program:  Pacific Center for Emerging Infectious Diseases Research (EID)

RMATRIX:  PI – Dean Jerris Hedges-RCMI Multidisciplinary and Translational Research Infrastructure eXpansion (RMATRIX)

INBRE:  PI – Eric Holmes-Grant Program:  Idea Networks of Biomedical Research Excellence (INBRE II) , Hawai’i Statewide Research and Education Partnership (HSREP)

Our photo is of researcher Brittany Sato, of the Collier Lab at JABSOM. 


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